| Autor: |
Walliser, P, Benzie, C R, Kay, J E |
| Jazyk: |
angličtina |
| Rok vydání: |
1989 |
| Předmět: |
|
| Popis: |
The novel immunosuppressive drug FK-506 inhibits both cell-mediated and humoral immunity in vivo and suppresses T-lymphocyte activation at nanamolar concentrations in vitro. We report here that FK-506 also inhibits the in vitro proliferation of murine B lymphocytes induced by goat antimouse IgM (GaMIgM), although it does not affect the induction of proliferation by bacterial lipopolysaccharide (LPS). The action of FK-506 on B-lymphocyte proliferation thus resembles that of cyclosporin A, further strengthening the correlation between the action of the two immunosuppressive drugs previously reported for T-lymphocyte activation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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