[Evaluation of the effectiveness of drug therapy of autonomic paroxysms in relation to the variability of cardiac rhythm]

Autor: N B, Khaspekova, M M, Loseva, E M, Kuterman
Rok vydání: 1991
Předmět:
Zdroj: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952). 91(5)
ISSN: 0044-4588
Popis: A study was made of changes in the amplitude and percentile contribution of respiratory waves and slow waves of heart rhythm (SW1 with a period of 8-14 s and SW2 with a period of 14-60 s) in 13 patients with panic attacks (PA) in the lying position after the 3-day monotherapy with the beta-blocker propranolol, alpha-blocker phentolamine and diazepam. Propranolol normalized baroreflex regulation of arterial pressure and raised SW1. Phentolamine, producing an analogous effect, enhanced sympathoadrenal activation and the rate of PA, reducing RW. The amplitude of SW2 that correlated with emotional tension and anxiety fell only as a result of the administration of diazepam. The latter drug did not influence the baroreflex (via SW1) and vagal (via RW) mechanisms of regulation.
Databáze: OpenAIRE