Effects of oral continuous and transdermal cyclic 17-beta estradiol and norethindrone acetate replacement therapy on platelet aggregation in postmenopausal women

Autor:	Petek Balkanli, Kaplan, Fatih, Gücer, N Cenk, Sayin, M Ali, Yüce, Turgut, Yardim
Rok vydání:	2002
Předmět:	Adult Time Factors Estradiol Platelet Aggregation Platelet Count Estrogen Replacement Therapy Age Factors Administration Oral Middle Aged Administration Cutaneous Lipids Norethindrone Acetate Delayed-Action Preparations Humans Drug Therapy Combination Female Prospective Studies Norethindrone
Zdroj:	The Journal of reproductive medicine. 47(8)
ISSN:	0024-7758
Popis:	To evaluate the effects of an oral continuous and transdermal cyclic 17-beta estradiol and norethindrone acetate combination on platelet aggregation in post-menopausal women.Fifty postmenopausal women were randomly assigned to receive 17-beta estradiol and norethindrone acetate either orally continuously or transdermally cyclically and sequentially. Platelet counts and maximum platelet aggregation rates were measured before and after three months treatment.At three months there were no significant changes in platelet counts or in adenosine diphosphate-induced or epinephrine-induced platelet aggregation rates in either treatment group.Hormone replacement treatment with a 17-beta estradiol and norethindrone acetate combination either orally continuously or transdermally cyclically and sequentially does not affect platelet aggregation in postmenopausal women.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5e67340be2c80b65e67ddc4d55e6b7e8 https://pubmed.ncbi.nlm.nih.gov/12216432 Zobrazit plný text záznamu