| Autor: |
Guillermo, Menga, Mariano, Fernandez Acquier, Andrés L, Echazarreta, Patricia B, Sorroche, Maria V, Lorenzon, Martin E, Fernández, María S, Saez |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Archivos de bronconeumologia. 56(9) |
| ISSN: |
2173-5751 |
| Popis: |
Alpha-1 antitrypsin deficiency (AATD) is still underdiagnosed, despite the recommendation to determine AAT in patients with chronic obstructive pulmonary disease (COPD).To estimate the prevalence of AATD in COPD patients adjusted according to the population of the COPD prevalence study in Argentina (EPOC.AR).This was a multicenter prospective cross-sectional study of a population aged≥30 years of age diagnosed with COPD, involving AAT quantification in dry blood spot and subsequent genotyping in subjects with1.5mg/dL AAT in dry blood spot (80mg/dL in serum). AAT was defined as the detection of variants ZZ or SZ on genotyping. The EPOC.AR study population was used to calculate local adjusted prevalence.We included 3,254 patients (544 with AAT80mg/dL) with a spirometric diagnosis of COPD. The prevalence of AATD in the total study population was 1.29% (95% CI 0.93-1.74), of which 0.92% (95% CI 0.62-1.31) were Pi*ZZ and 0.37% (95% CI 0.19-0.64) Pi*SZ. The adjusted prevalence of AATD in COPD patients≥40 years of age was 0.83% (95% CI 0.23-2.08). We found that AATD was negatively associated with age (OR 0.94; 95% CI 0.90-0.98; P=.006), smoking habit (OR 0.98; 95% CI 0.96-0.99; P=.009), and FEVThe prevalence of AATD in the adult population with COPD in Argentina is estimated to be 0.83%, which could represent 17,000 cases in our country. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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