| Autor: |
Y, Ye, M, Niekrasz, M, Kehoe, L L, Rolf, M, Martin, J, Baker, S, Kosanke, E, Romano, N, Zuhdi, D K, Cooper |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Laboratory animal science. 44(2) |
| ISSN: |
0023-6764 |
| Popis: |
The baboon, like the human, expresses A and/or B blood group antigens on its tissues. Anti-A and anti-B antibodies are directed against these antigens, the epitopes of which are carbohydrate structures. Portions of these carbohydrates have been synthesized (trisaccharides A and B, respectively). When infused intravenously, the synthetic trisaccharides form a complex with the specific antibodies and neutralize their activity preventing them from binding to the antigen targets on a transplanted organ. In nonimmunosuppressed, hyperimmunized baboons, the continuous intravenous infusion of the specific trisaccharide alone (for 6 days) inhibited rejection of ABO-incompatible cardiac allografts, extending survival from a mean of 19 min (n = 3) to 8 days (n = 2), at which time the grafts failed from cellular (not vascular) rejection. The combination of long-term pharmacologic immunosuppression plus trisaccharide infusion (for periods of 8 to 19 days) extended survival to a mean of28 days (n = 4) with one heart functioning52 days. Accommodation clearly occurred in three of the four cases. This form of therapy may permit cadaveric organ allotransplantation across the ABO blood-group barrier in the human. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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