| Autor: |
Per M, Arvidsson, Anders, Nelsson, Jonathan, Edlund, J Gustav, Smith, Martin, Magnusson, Ning, Jin, Einar, Heiberg, Marcus, Carlsson, Katarina, Steding-Ehrenborg, Håkan, Arheden |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of applied physiology (Bethesda, Md. : 1985). 133(3) |
| ISSN: |
1522-1601 |
| Popis: |
Kinetic energy (KE) of intracardiac blood flow reflects myocardial work spent on accelerating blood and provides a mechanistic window into diastolic filling dynamics. Diastolic dysfunction may represent an early stage in the development of heart failure (HF). Here we evaluated the hemodynamic effects of impaired diastolic function in subjects with and without HF, testing the hypothesis that left ventricular KE differs between controls, subjects with subclinical diastolic dysfunction (SDD), and patients with HF. We studied 77 subjects [16 controls, 20 subjects with SDD, 16 heart failure with preserved ejection fraction (HFpEF), 9 heart failure with mildly reduced ejection fraction (HFmrEF), and 16 heart failure with reduced ejection fraction (HFrEF) patients, age- and sex-matched at the group level]. Cardiac magnetic resonance at 1.5 T included intracardiac four-dimensional (4-D) flow and cine imaging. Left ventricular KE was calculated as 0.5 × |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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