Changes in reactivity of rat arteries subjected to dynamic stretch

Autor:	D P, Dvoretsky, V N, Yartsev, O V, Karachentseva, M P, Granstrem
Rok vydání:	2000
Předmět:	Male Tail Serotonin Vasodilator Agents Free Radical Scavengers Tetrodotoxin Nitroarginine Acetylcholine Electric Stimulation Stimulation Chemical Mesenteric Arteries Rats Norepinephrine Vasoconstriction Animals Vasoconstrictor Agents Stress Mechanical Enzyme Inhibitors Rats Wistar
Zdroj:	Acta physiologica Scandinavica. 169(1)
ISSN:	0001-6772
Popis:	The effect of dynamic stretch on the reactivity of the rat tail and mesenteric artery segments was studied. Segments mounted on a myograph were stretched by a computer-controlled motorized micromanipulator. Dynamic stretch (1, 5 or 7 Hz) inhibited the artery constriction induced by noradrenaline (10 microM), 5-hydroxytryptamine (0.7 microM), or electrical field stimulation of intramural nerves. In contrast, dynamic stretch enhanced the tetrodotoxin-insensitive dilation induced by electrical field stimulation of noradrenaline-contracted arteries. Maximal increase of dilation evoked by electrical field stimulation (24.5 +/- 5.0% in mesenteric and 50.3 +/- 15.6% in the tail artery) was observed at a dynamic stretch-frequency of 5 Hz. An inhibitor of nitric oxide synthesis, NG-nitro-L-arginine (100 microM), abolished the difference in reactivity between static and dynamic conditions. The results indicate that dynamic stretch of the arteries activates nitric oxide synthesis/secretion, thus reducing constrictor and increasing dilator responses to the stimuli used.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5dff89c9d018159bbcc32a0c000df752 https://pubmed.ncbi.nlm.nih.gov/10759606 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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