Autor: |
Naoki, Hosen, Yukiko, Matsunaga, Kana, Hasegawa, Hiroshi, Matsuno, Yuki, Nakamura, Mio, Makita, Kouki, Watanabe, Mikako, Yoshida, Kei, Satoh, Soyoko, Morimoto, Fumihiro, Fujiki, Hiroko, Nakajima, Jun, Nakata, Sumiyuki, Nishida, Akihiro, Tsuboi, Yoshihiro, Oka, Masahiro, Manabe, Hiroyoshi, Ichihara, Yasutaka, Aoyama, Atsuko, Mugitani, Takafumi, Nakao, Masayuki, Hino, Ryosuke, Uchibori, Keiya, Ozawa, Yoshihiro, Baba, Seitaro, Terakura, Naoki, Wada, Eiichi, Morii, Junichi, Nishimura, Kiyoshi, Takeda, Yusuke, Oji, Haruo, Sugiyama, Junichi, Takagi, Atsushi, Kumanogoh |
Rok vydání: |
2017 |
Předmět: |
|
Zdroj: |
Nature medicine. 23(12) |
ISSN: |
1546-170X |
Popis: |
Cancer-specific cell-surface antigens are ideal targets for monoclonal antibody (mAb)-based immunotherapy but are likely to have previously been identified in transcriptome or proteome analyses. Here, we show that the active conformer of an integrin can serve as a specific therapeutic target for multiple myeloma (MM). We screened10,000 anti-MM mAb clones and identified MMG49 as an MM-specific mAb specifically recognizing a subset of integrin β |
Databáze: |
OpenAIRE |
Externí odkaz: |
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