The activated conformation of integrin β

Autor:	Naoki, Hosen, Yukiko, Matsunaga, Kana, Hasegawa, Hiroshi, Matsuno, Yuki, Nakamura, Mio, Makita, Kouki, Watanabe, Mikako, Yoshida, Kei, Satoh, Soyoko, Morimoto, Fumihiro, Fujiki, Hiroko, Nakajima, Jun, Nakata, Sumiyuki, Nishida, Akihiro, Tsuboi, Yoshihiro, Oka, Masahiro, Manabe, Hiroyoshi, Ichihara, Yasutaka, Aoyama, Atsuko, Mugitani, Takafumi, Nakao, Masayuki, Hino, Ryosuke, Uchibori, Keiya, Ozawa, Yoshihiro, Baba, Seitaro, Terakura, Naoki, Wada, Eiichi, Morii, Junichi, Nishimura, Kiyoshi, Takeda, Yusuke, Oji, Haruo, Sugiyama, Junichi, Takagi, Atsushi, Kumanogoh
Rok vydání:	2017
Předmět:	Integrin beta Chains Protein Conformation Recombinant Fusion Proteins T-Lymphocytes Receptors Antigen T-Cell Mice Transgenic Mice SCID Immunotherapy Adoptive Xenograft Model Antitumor Assays Article Mice HEK293 Cells Mice Inbred NOD Cell Line Tumor Animals Humans Female K562 Cells Multiple Myeloma human activities
Zdroj:	Nature medicine. 23(12)
ISSN:	1546-170X
Popis:	Cancer-specific cell-surface antigens are ideal targets for monoclonal antibody (mAb)-based immunotherapy but are likely to have previously been identified in transcriptome or proteome analyses. Here, we show that the active conformer of an integrin can serve as a specific therapeutic target for multiple myeloma (MM). We screened10,000 anti-MM mAb clones and identified MMG49 as an MM-specific mAb specifically recognizing a subset of integrin β
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5ded4449e3ee61c33d668d8961541fcb https://pubmed.ncbi.nlm.nih.gov/29216041 Zobrazit plný text záznamu Full text from SpringerLink