| Autor: |
N, Shuke, T, Takashio, J, Sato, Y, Ishikawa, Y, Saito, W, Yamamoto, T, Aburano, M, Mizunaga, S, Kaneko, S, Yachiku, Y, Ogawa, K, Kikuchi, T, Sasajima, Y, Kubo |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Kaku igaku. The Japanese journal of nuclear medicine. 33(5) |
| ISSN: |
0022-7854 |
| Popis: |
We studied 50 patients with mild to moderate renal dysfunction to compare pharmacokinetics of 99mTc-MAG3 with that of 131I-OIH. After simultaneous bolus injection of both 99mTc-MAG3 and 131I-OIH, 8-point venous blood sampling was performed from 2 to 44 min post injection. Aliquoted plasma samples were counted for radioactivity along with the injected standard to obtain % injected dose/ml plasma for each tracer. Using obtained time-concentration data, classical 2 compartment model analysis was performed for both tracers to obtain various pharmacokinetic parameters, including distribution volumes (Vds), inter-compartmental rate constants, and plasma clearance. In these parameters, Vd of central compartment, Vd at steady state, central to peripheral inter-compartmental rate constant, and plasma clearance were significantly larger for 131I-OIH. In all parameters, significant correlation was found between 99mTc-MAG3 and 131I-OIH. The best correlation was seen in plasma clearance (r = 0.891, p0.0001). Plasma clearance ratio (99mTc-MAG3/131I-OIH), however, showed weak but significant negative correlation with serum creatinine, although this correlation was not likely to affect the overall correlation of clearance between 131I-OIH and 99mTc-MAG3. From these results, we confirmed that 99mTc-MAG3 clearance could be used as an alternative to 131I-OIH clearance, although pharmacokinetic behavior of 99mTc-MAG3 was not exactly the same as that of 131I-OIH. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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