Bleomycin/cis-platin as neoadjuvant chemotherapy before radical radiotherapy in localized, inoperable carcinoma of the esophagus. A prospective randomized multicentre study: the second Scandinavian trial in esophageal cancer

Autor: R, Hatlevoll, S, Hagen, H S, Hansen, R, Hultborn, A, Jakobsen, M, Mäntylä, H, Modig, E, Munck-Wikland, K, Nygaard, B, Rosengren
Rok vydání: 1992
Předmět:
Zdroj: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 24(2)
ISSN: 0167-8140
Popis: Survival and swallowing function were studied in a randomized trial of 97 patients with inoperable, localized esophageal carcinoma. Radical radiotherapy was given to 51 patients, while 46 patients had two courses of bleomycin/cisplatin before radiotherapy. The survival was 29% after one year, and 6% after 3 years in the radiotherapy group. The survival in the combined treatment group was 18 and 0%, respectively; p = 0.1895. The number of patients who could swallow any food increased from 6% before treatment to 38% after 3 months in the radiotherapy group, and from 0% to 23% in the combined group. No benefit was found by combining bleomycin/cisplatin with radiotherapy.
Databáze: OpenAIRE