| Autor: |
Yu-Jiao, Meng, Yu, Liu, Zheng-Rong, Liu, Zhao-Xia, Chen, Ting-Ting, Di, Jing-Xia, Zhao, Yan, Wang, Ping, Li |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Zhongguo zhen jiu = Chinese acupuncturemoxibustion. 42(1) |
| ISSN: |
0255-2930 |
| Popis: |
To observe the effect of moxibustion on skin lesions and immune inflammatory response in psoriasis mice, and to explore the possible mechanism of moxibustion for psoriasis.A total of 32 male BALB/c mice were randomly divided into a normal group, a model group, a moxibustion group and a medication group, 8 mice in each group. Psoriasis model was induced by applying 5% imiquimod cream on the back for 7 days in the model group, the moxibustion group and the medication group. At the same time of model establishment, the moxibustion group was treated with suspension moxibustion on skin lesions on the back, 20 min each time, once a day; the medication group was treated with 1 mg/kg methotrexate tablet solution by gavage, once a day. Both groups were intervened for 7 days. The daily changes of skin lesions were observed, and the psoriasis area and severity index (PASI) score was evaluated; the histopathological changes of skin lesions were observed by HE staining; the positive expression of proliferating cell nuclear antigen (PCNA) and T lymphocyte surface marker CDThe increased and hypertrophy scale, dry skin, red and swollen epidermis and obvious infiltration were observed in the model group, and each score and total score of PASI were higher than those in the normal group (Moxibustion could effectively improve the scale and infiltration of skin lesions in psoriasis mice. Its mechanism may be related to inhibiting inflammatory response and regulating immunity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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