Pneumococcal carriage in households in Karonga District, Malawi, before and after introduction of 13-valent pneumococcal conjugate vaccination
| Autor: | Ellen, Heinsbroek, Terence, Tafatatha, Amos, Phiri, Todd D, Swarthout, Maaike, Alaerts, Amelia C, Crampin, Christina, Chisambo, Oddie, Mwiba, Jonathan M, Read, Neil, French |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Rural Population Family Characteristics Malawi Carriage Time Factors Adolescent Pneumococcal conjugate vaccine Vaccination Infant Pneumococcal Infections Article Cohort Studies Pneumococcal Vaccines Cross-Sectional Studies Streptococcus pneumoniae Child Preschool Nasopharynx Carrier State Africa Humans Female Serotyping Child |
| Zdroj: | Vaccine |
| ISSN: | 1873-2518 |
| Popis: | Highlights • Pneumococcal carriage of any serotype remained high three years post vaccine introduction. • Early acquisition of pneumococcal carriage in infants continued post vaccine introduction. • Vaccine-type carriage was lower in vaccinated and unvaccinated individuals. • Non-vaccine-type carriage was higher post vaccine introduction in vaccinated children. • There is evidence of herd protection and serotype replacement in this population. Background Thirteen-valent pneumococcal conjugate vaccine (PCV13) was introduced in Malawi in November 2011 and is offered to infants at 6, 10 and 14 weeks of age as part of routine immunisation. PCV13 is expected to reduce vaccine type (VT) nasopharyngeal carriage, leading to reduced transmission and herd protection. Methods We compared pneumococcal carriage in rural Karonga District, Malawi, pre-vaccine in 2009–2011 and post-vaccine in 2014 using a combination of cross-sectional and longitudinal analyses. Nasopharyngeal swabs were collected from a cohort of mother-infant pairs and household members |
| Databáze: | OpenAIRE |
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