| Autor: |
J S, Pinto, L, Sobrinho, M B, da Silva, M T, Porto, M A, Santos, M, Baló-Banga, M, Arala-Chaves |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
Dermatologica. 180(3) |
| ISSN: |
0011-9075 |
| Popis: |
We report a case of a 23-year-old woman who was afflicted with disseminated skin erythema multiforme-like eruptions that started at the menarche, relapsed at the premenstrual periods, dramatically spread during two pregnancies and cleared after abortion; the skin lesions responded dramatically to thalidomide treatment. A high-affinity binding factor to 17 alpha-hydroxyprogesterone (17-OHP) was found in the serum of this patient. Her lymphocytes did not proliferate in vitro after exposure to exogenous 17-OHP but showed significant chromatin activation. There was a decreased expression of HLA antigens at the surface of the patient's blood lymphocytes. This is a unique well-documented case of erythema multiforme most possibly due to autoreactivity to 17-OHP; the precise mechanism(s) of this autoreactivity has not been established. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
