Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABA

Autor:	Longjiang, Huang, Jing, Ding, Min, Li, Zhipeng, Hou, Yanru, Geng, Xiufen, Li, Haibo, Yu
Rok vydání:	2019
Předmět:	Electroshock Dose-Response Relationship Drug Molecular Structure Motor Activity Triazoles Protective Agents Receptors GABA-A Mice Inbred C57BL Mice Structure-Activity Relationship Pyrimidines Seizures Drug Discovery Animals Pentylenetetrazole Anticonvulsants Cells Cultured
Zdroj:	European journal of medicinal chemistry. 185
ISSN:	1768-3254
Popis:	In searching for more effective and safer antiepileptic drugs, a series of 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidine-7(4H)-one derivatives were designed and synthesized. Spontaneous Ca
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5d24f48157db4c52337f5f553aa39bff https://pubmed.ncbi.nlm.nih.gov/31708184 Zobrazit plný text záznamu Full Text from ScienceDirect