ATP triggers a robust intracellular [Ca

Autor: C, Kondo, R B, Clark, N, Al‐Jezani, T Y, Kim, D, Belke, U, Banderali, R T, Szerencsei, A H, Jalloul, P P M, Schnetkamp, K W, Spitzer, W R, Giles
Rok vydání: 2017
Předmět:
Zdroj: Experimental physiology. 103(8)
ISSN: 1469-445X
Popis: What is the central question of this study? What are the main [CaIn human articular joints, synovial fibroblasts (HSFs) have essential physiological functions that include synthesis and secretion of components of the extracellular matrix and essential articular joint lubricants, as well as release of paracrine substances such as ATP. Although the molecular and cellular processes that lead to a rheumatoid arthritis (RA) phenotype are not fully understood, HSF cells exhibit significant changes during this disease progression. The effects of ATP on HSFs were studied by monitoring changes in intracellular Ca
Databáze: OpenAIRE