Association of
| Autor: | Renaud, La Joie, Adrienne V, Visani, Orit H, Lesman-Segev, Suzanne L, Baker, Lauren, Edwards, Leonardo, Iaccarino, David N, Soleimani-Meigooni, Taylor, Mellinger, Mustafa, Janabi, Zachary A, Miller, David C, Perry, Julie, Pham, Amelia, Strom, Maria Luisa, Gorno-Tempini, Howard J, Rosen, Bruce L, Miller, William J, Jagust, Gil D, Rabinovici |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Genotype Apolipoprotein E4 tau Proteins Alzheimer Disease Parietal Lobe Humans Visual Pathways Aged Retrospective Studies Aged 80 and over Cerebral Cortex Amyloid beta-Peptides Aniline Compounds Middle Aged Mental Status and Dementia Tests Magnetic Resonance Imaging Temporal Lobe Frontal Lobe Thiazoles Aphasia Primary Progressive Phenotype Positron-Emission Tomography Female Occipital Lobe Radiopharmaceuticals Carbolines |
| Zdroj: | Neurology. 96(5) |
| ISSN: | 1526-632X |
| Popis: | To assess whether Alzheimer disease (AD) clinical presentation andWe studied 119 Aβ-positive symptomatic patients aged 48-95 years, including 29 patients with logopenic variant primary progressive aphasia (lvPPA) and 21 with posterior cortical atrophy (PCA). Pittsburgh compound B (PiB)-Aβ and flortaucipir (tau)-PET standardized uptake value ratio (SUVR) images were created. General linear models assessed relationships between demographic/clinical variables (phenotype, age),PiB-PET binding showed a widespread cortical distribution with subtle differences across phenotypes and was unrelated to demographic/clinical variables orClinical phenotypes are associated with differential patterns of tau but not amyloid pathology. Older age and |
| Databáze: | OpenAIRE |
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