| Autor: |
C, Friesen, I, Hormann, M, Roscher, S, Bacher, E, Miltner |
| Jazyk: |
němčina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Nuklearmedizin. Nuclear medicine. 49 |
| ISSN: |
0029-5566 |
| Popis: |
Despite good achievements in prevention and control, cancer is still a leading cause of death worldwide. The development of resistances against conventional treatment modalities is one of the main causes of failure in the treatment of cancer. Radio- and chemotherapies fail frequently due to intrinsic or acquired resistances in apoptotic signalling pathways or alterations in DNA-repair processes. Targeted radiotherapies employing α-particle-emitting radionuclides and Auger-emitting electrons are a promising approach in cancer treatment to break radio- and chemoresistance by overcoming DNA-repair mechanisms and reversing deficient activation of apoptotic pathways in cancer cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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