| Autor: |
J K, Wright, C A, Penning, J C, Ashby, J, Cunningham, N R, Rowell, P, Hughes |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
Journal of clinicallaboratory immunology. 11(2) |
| ISSN: |
0141-2760 |
| Popis: |
Sera from 6 out of 18 patients with systemic lupus erythematosus (SLE) were found to be capable of producing marked increases of cytotoxicity in several established human target cell lines when co-cultured with normal human peripheral blood mononuclear cells (PBM). Fractionation studies indicated that the cytotoxicity-inducing activity resided in IgG containing fractions and that the effector cells were Fc-receptor positive. By contrast, sera from 27 normal controls produced little or no cytotoxicity when similarly co-cultured with the same target cell lines and normal PBM. Any slight reactivity that occasionally occurred against a single cell line was, on serum fractionation, either labile or associated with albumen containing fractions. These findings raise the possibility that antibody-dependent cellular cytotoxicity could provide an additional pathogenetic mechanism in patients with SLE. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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