Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice

Autor:	Feng-Shiun, Shie, Renée C, LeBoeuf, Lee-Way, Jin, Renée C, LeBoeur
Rok vydání:	2003
Předmět:	Intracellular Fluid Neurons Aging Amyloid beta-Peptides Mutation Missense Mice Transgenic Plaque Amyloid Dietary Fats Hippocampus Cholesterol Dietary Amyloid beta-Protein Precursor Mice Amino Acid Substitution Models Animal Animals Point Mutation Female Lysosomes Crosses Genetic
Zdroj:	Neuroreport. 14(1)
ISSN:	0959-4965
Popis:	Increasing evidence suggests that intraneuronal amyloid-beta (Abeta) accumulation may be an early event in Alzheimer's disease (AD) pathogenesis. However direct in vivo evidence regarding initial Abeta seeding is missing. Using an APP transgenic mouse model, our sensitive immunocytochemical procedures revealed a novel intraneuronal Abeta deposition in the somas of hippocampal CA1/subiculum neurons far in advance of the occurrence of extracellular Abetaplaques. These deposits increased exponentially with age and were elevated approximately 4-fold (p0.001) by high fat/high cholesterol diet. Abeta40 and Abeta42 were the major constituents of these deposits and were co-localized with lysosomal markers. Our results are consistent with the notion that the earliest Abeta deposition occurs intraneuronally, prior to extracellular amyloid plaque formation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5c18050fbea1e1fb137f335fd23606e0 https://pubmed.ncbi.nlm.nih.gov/12544843 Zobrazit plný text záznamu