| Autor: |
Rediet, Tesfaye, Abel, Degu, Besufekad, Abebe, Hiwot, Ayalew |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Journal of Inflammation Research |
| ISSN: |
1178-7031 |
| Popis: |
Introduction Pain and inflammatory disorders are the most prevalent syndromes. Different herbs were used for treatment of pain and inflammation including members of the genus Otostegia. As a result, this research investigated the in vivo analgesic and anti-inflammatory effects of 80% methanol leaf extract of Otostegia integrifolia in mice. Methods The analgesic and anti-inflammatory effects of the plant was evaluated using hot plate method, acetic-acid induced writhing test, and carrageenan and formalin induced paw edema. Three experimental groups (100, 200, and 400 mg/kg) received the extract while morphine 10 mg/kg and aspirin 150 mg/kg were used as a positive control for analgesic and anti-inflammatory tests accordingly. Distilled water (10 mL/kg) was used as negative control. Results From the experimental groups, OI400 displayed significant analgesic and anti-inflammatory activities (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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