Cine dyscontractility index: A novel marker of mechanical dyssynchrony that predicts response to cardiac resynchronization therapy
| Autor: | Konrad, Werys, Joanna, Petryka-Mazurkiewicz, Łukasz, Błaszczyk, Jolanta, Miśko, Mateusz, Śpiewak, Łukasz A, Małek, Łukasz, Mazurkiewicz, Barbara, Miłosz-Wieczorek, Magdalena, Marczak, Agata, Kubik, Agnieszka, Dąbrowska, Ewa, Piątkowska-Janko, Błażej, Sawionek, Rohan, Wijesurendra, Stefan K, Piechnik, Piotr, Bogorodzki |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Heart Failure Male Magnetic Resonance Imaging Cine Reproducibility of Results Stroke Volume Middle Aged Prognosis Myocardial Contraction Sensitivity and Specificity Cardiac Resynchronization Therapy Ventricular Dysfunction Left Treatment Outcome Image Interpretation Computer-Assisted Humans Female Biomarkers Excitation Contraction Coupling |
| Zdroj: | Journal of magnetic resonance imaging : JMRI. 44(6) |
| ISSN: | 1522-2586 |
| Popis: | To investigate whether magnetic resonance imaging (MRI) cine-derived dyssynchrony indices provide additional information compared to conventional tagged MRI (tMRI) acquisitions in heart failure patients undergoing cardiac resynchronization therapy (CRT).Patients scheduled for CRT (n = 52) underwent preprocedure MRI including cine and tMRI acquisitions. Segmental strain curves were calculated for both cine and tMRI to produce a range of standard indices for direct comparison between modalities. We also proposed and evaluated a novel index of "dyscontractility," which detects the presence of focal areas with paradoxically positive circumferential strain.Across conventional strain indices, there was only moderate-to-poor (R = 0.3-0.6) correlation between modalities; eight cine-derived indices showed statistically significant (P0.05) relations to CRT outcome compared to just two tMRI-based counterparts. The novel dyscontractility index calculated on basal slice cine images (cine dyscontractility index, "CDI") was the single best predictor of clinical response to CRT (area under the curve AUC = 0.81, P0.001). While poorly correlated to its tMRI counterpart (R = 0.33), CDI performed significantly better in predicting response to CRT (P0.005), and was also numerically better than all other tMRI indices (AUC 0.53-0.76, all P for AUC comparisons0.17).Cine-derived strain indices offer potentially new information compared to tMRI. Specifically, the novel CDI is most strongly linked to response to cardiac resynchronization therapy in a contemporary patient cohort. It utilizes readily available MRI data, is relatively straightforward to process, and compares favorably with any conventional tagging index. J. Magn. Reson. Imaging 2016;44:1483-1492. |
| Databáze: | OpenAIRE |
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