| Autor: |
S V, Pinchuk, I B, Vasilevich, Z B, Kvacheva, I D, Volotovski |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Tsitologiia. 58(7) |
| ISSN: |
0041-3771 |
| Popis: |
The human adipose-derived mesenchymal stem cells was shown to be hepatic differentiated under influence of inductor factors. The differentiation of MSCs was induced by fibroblast growth factor-4, hepatocyte growth factor, oncostatin M and dexamethasone. The influence of quercetin on the hepatic differentiation of MSCs in culture was investigated. The adding quercetin into induction medium (1 or 10 mmol/l) enhanced the manifestation of signs of hepatic differentiation MSCs such as urea secretion, cytokeratin 19 and a-fetoprotein synthesis. Quercetin modulating action on the CYP1A — cytochrome P450 activity in differentiated cells was found. MSCs which was differentiated in the presence of quercetin had a higher viability and resistance to oxidative stress. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
