[Lipoprotein (a) and ischemic heart diseases in patients with type 2 diabetes]
| Autor: | K, Ben Hamda, A S, Masmoudi, O, Mandhouj, S, Hammami, N, Attia, M, Smaoui, M A, Zidi, N, Nabli, R, Chaaba, S, Mahjoub, M, Ben Farhat, M, Hammami |
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| Jazyk: | francouzština |
| Rok vydání: | 2004 |
| Předmět: |
Hypertriglyceridemia
Male Hyperlipoproteinemias Tunisia Apolipoprotein A-I Cholesterol HDL Hypercholesterolemia Myocardial Ischemia Cholesterol LDL Middle Aged Cholesterol Diabetes Mellitus Type 2 Risk Factors Case-Control Studies Linear Models Humans Female Triglycerides Apolipoproteins B Lipoprotein(a) |
| Zdroj: | Archives de l'Institut Pasteur de Tunis. 79(1-4) |
| ISSN: | 0020-2509 |
| Popis: | Lipoprotein (a) is a new independent coronary risk factor, but the role of lipoprotein (a) in type 2 diabetes remains controversial. The objective of this study was to demonstrate the relationship between the level of lipoprotein (a) and the coronary artery diseases (CAD) in type 2 diabetes. Recruitment was carried out in 3 groups of patients: Group 1: 110 control subjects, Group 2: 115 diabetics (D), Group 3: 105 diabetics with CAD (DC). The mean age was, 51 + 7; 52 + 6; 56 + 6 respectively. Total cholesterol, triglyceride, HDL-C, LDL-C, Apo A-I, Apo B and lipoprotein (a) were measured for the patients. The Lp (a) level was significantly higher in the diabetic groups as compared to the controls (p0.05), but this level was different between D and DC: 312 + 232 vs 347.8 + (NS). However, when the Lp (a) level is higher than 300 mg/ml, there is a significant difference between DC and D (53% vs 42% p = 0.05). There is no correlation between Lp level and total cholesterol; however, there is a significant variation of Lp (a) level with LDL-C (r = -0.14, P = 0.01). There is a negative correlation between Lp (a) and HDL-C (r = -0.13, p = 0.03), Lp (a) and ApoA-I (r = - 0.11, p = 0.05); but there is a positive correlation between Lp (a) and ApoB (r = 0.14, p = 0.02). Lp(a) level higher than 300 mg/L constitutes a coronary risk factor in type 2 diabetes. This contributes, with the other lipid disorders, to the increase of the coronary risk factors in diabetes. |
| Databáze: | OpenAIRE |
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