Evaluation of cytotoxic effects of fungal origin nanosilver particles on oral cancer cell lines: An

Autor:	Kiran R, Halkai, Rahul, Halkai, Supriya, Patil, Jameela, Alawadi, Wafa Saeed, Alawadhi, Narender Reddy, Marukala, Nassreen Hassan, Mohammad Albar, Shreeshail, Indi
Rok vydání:	2022
Předmět:	Silver Plant Extracts Carcinoma Squamous Cell Humans Metal Nanoparticles Mouth Neoplasms Cell Line
Zdroj:	Journal of cancer research and therapeutics. 18(1)
ISSN:	1998-4138
Popis:	Oral cancer is often associated with poor prognosis and it is found that conventional treatment options cause severe side effects, adjacent tissue disfigurement, and loss of function. Recently, silver nanoparticles (AgNPs) paved their path for cancer treatment.This study aimed to investigate cytotoxic effects of fungal procured AgNPs on oral squamous cell carcinoma (SCC-9) cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay.The silver nanoparticles were biosynthesized using the fungi Fusarium semitectum. Cell lines were cultured in a 1:1 ratio of Dulbecco's Modified Eagle's medium and Ham's F12 medium and subcultured in a T-75 cmSignificant dose-dependent inhibition of the growth of SCC-9 cell lines was seen and ICBiosynthesized AgNPs of fungal origin exhibit effective anticancer properties against the SCC-9 cell line.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5bdb67ec82fbaed9ea966c050f08aa7f https://pubmed.ncbi.nlm.nih.gov/35381790 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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