Performance on the Modified Card Sorting Test and its relation to psychopathology in adolescents and young adults with 22q11.2 deletion syndrome
| Autor: | K, Rockers, O, Ousley, T, Sutton, E, Schoenberg, K, Coleman, E, Walker, J F, Cubells |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Chromosome Aberrations Male Psychiatric Status Rating Scales Adolescent Psychometrics Psychopathology Chromosomes Human Pair 22 Mental Disorders Decision Making Syndrome Neuropsychological Tests Schizotypal Personality Disorder Young Adult Reference Values Intellectual Disability Schizophrenia Humans Female Schizophrenic Psychology Chromosome Deletion Cognition Disorders Internal-External Control Problem Solving |
| Zdroj: | Journal of intellectual disability research : JIDR. 53(7) |
| ISSN: | 1365-2788 |
| Popis: | Approximately one-third of individuals with 22q11.2 deletion syndrome (22q11DS), a common genetic disorder highly associated with intellectual disabilities, may develop schizophrenia, likely preceded by a mild to moderate cognitive decline.We examined adolescents and young adults with 22q11DS for the presence of executive function deficits using a modified version of the Wisconsin Card Sorting Test (MCST) and assessed whether specific performances were associated with concurrent schizophrenia-prodrome symptoms. We also examined possible relationships between MCST performance and broader indices of psychopathology, including self-reported internalising and externalising behavioural symptoms.Participants with 22q11DS scored significantly below age-matched controls on seven out of nine MCST measures, and poorer MCST performance was associated with increased positive prodromal and internalising behavioural symptoms.The schizophrenia-prodrome in 22q11DS involves executive dysfunction, and longitudinal investigation is necessary to examine if specific executive function impairments precedes or co-occurs with the emergence of behavioural psychopathology. |
| Databáze: | OpenAIRE |
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