Relationship between radiographic grading of osteoarthritis and the biochemical markers for arthritis in knee osteoarthritis
| Autor: | Masaaki, Takahashi, Kenichi, Naito, Masashi, Abe, Tomokazu, Sawada, Akira, Nagano |
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| Rok vydání: | 2003 |
| Předmět: |
musculoskeletal diseases
markers Spinal Osteophytosis Adipokines generalized osteoarthritis Lectins Osteoarthritis Humans Chitinase-3-Like Protein 1 Amino Acids Aged Glycoproteins Aged 80 and over Tissue Inhibitor of Metalloproteinase-1 radiographic grading Middle Aged Osteoarthritis Knee Hand Postmenopause Radiography C-Reactive Protein Matrix Metalloproteinase 9 Disease Progression Female Matrix Metalloproteinase 3 Biomarkers Research Article |
| Zdroj: | Arthritis Research & Therapy |
| ISSN: | 1478-6362 |
| Popis: | The aim of this study was to investigate the relationship between the biochemical markers of arthritis and the radiographic grading of osteoarthritis (OA) in knees. Seventy-one women aged 49–85 years with knee OA were studied. Anterior–posterior knee radiographs and hand radiographs were taken in all patients. The radiographic grading of OA in the knee was performed by using the Kellgren–Lawrence criteria and the joint space width. The 71 patients with knee OA were divided into two groups: 37 patients exhibiting generalized osteoarthritis (GOA) and 34 non-GOA patients, according to the grading of their hand radiograph. C-reactive protein (CRP), urinary pyridinoline, YKL-40, plasma matrix metalloproteinase (MMP)-3, MMP-9 and tissue inhibitor of metalloproteinases (TIMP)-1 were measured as the biochemical markers of arthritis. The radiographic grading with the Kellgren–Lawrence scale revealed a significant relationship to the joint space width (P = 0.003): the joint space width decreased with increasing Kellgren–Lawrence grade. All biochemical markers had negative correlations with the joint space width, but only urinary pyridinoline had a significant correlation (P = 0.039). Pyridinoline (P = 0.034) and TIMP-1 (P = 0.017) also exhibited a significant relationship to the Kellgren–Lawrence grade. In GOA evaluations, the joint space width did not differ between GOA and non-GOA patients. CRP, pyridinoline, YKL-40 and MMP-3 levels were significantly greater in GOA patients than in non-GOA patients. CRP, pyridinoline, YKL-40, MMP-3 and TIMP-1 levels each related to at least one of the radiographic gradings. Furthermore, pyridinoline related to every type of radiographic grading examined in the present study. |
| Databáze: | OpenAIRE |
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