Higher glucose, insulin and insulin resistance (HOMA-IR) in childhood predict adverse cardiovascular risk in early adulthood: the Pune Children's Study
| Autor: | Chittaranjan S, Yajnik, Prachi A, Katre, Suyog M, Joshi, Kalyanaraman, Kumaran, Dattatray S, Bhat, Himangi G, Lubree, Nilam, Memane, Arun S, Kinare, Anand N, Pandit, Sheila A, Bhave, Ashish, Bavdekar, Caroline H D, Fall |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male India Blood Pressure Pulse Wave Analysis Carotid Intima-Media Thickness Article Young Adult Indians Predictive Value of Tests Risk Factors Humans Insulin Obesity Child Childhood insulin resistance Sex Characteristics Diabetes Glucose Tolerance Test Cardiovascular risk Lipids Cardiovascular Diseases Child Preschool Female Insulin Resistance Follow-Up Studies Young adults |
| Zdroj: | Diabetologia |
| ISSN: | 1432-0428 |
| Popis: | Aims/hypothesis The Pune Children’s Study aimed to test whether glucose and insulin measurements in childhood predict cardiovascular risk factors in young adulthood. Methods We followed up 357 participants (75% follow-up) at 21 years of age who had undergone detailed measurements at 8 years of age (glucose, insulin, HOMA-IR and other indices). Oral glucose tolerance, anthropometry, plasma lipids, BP, carotid intima–media thickness (IMT) and arterial pulse wave velocity (PWV) were measured at 21 years. Results Higher fasting glucose, insulin and HOMA-IR at 8 years predicted higher glucose, insulin, HOMA-IR, BP, lipids and IMT at 21 years. A 1 SD change in 8 year variables was associated with a 0.10–0.27 SD change at 21 years independently of obesity/adiposity at 8 years of age. A greater rise in glucose–insulin variables between 8 and 21 years was associated with higher cardiovascular risk factors, including PWV. Participants whose HOMA-IR measurement remained in the highest quartile (n = 31) had a more adverse cardiovascular risk profile compared with those whose HOMA-IR measurement remained in the lowest quartile (n = 28). Conclusions/interpretation Prepubertal glucose–insulin metabolism is associated with adult cardiovascular risk and markers of atherosclerosis. Our results support interventions to improve glucose–insulin metabolism in childhood to reduce cardiovascular risk in later life. Electronic supplementary material The online version of this article (doi:10.1007/s00125-015-3602-z) contains peer-reviewed but unedited supplementary material, which is available to authorised users. |
| Databáze: | OpenAIRE |
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