| Autor: |
Meng, Wang, Jiansheng, Li, Liping, Wang, Xinfeng, Chen, Zhen, Zhang, Dongli, Yue, Yu, Ping, Xiaojuan, Shi, Lan, Huang, Tengfei, Zhang, Li, Yang, Yongfu, Zhao, Xiuxian, Ma, Dexu, Li, Zhengjun, Fan, Longshuan, Zhao, Zhe, Tang, Wenlong, Zhai, Bin, Zhang, Yi, Zhang |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
International journal of clinical and experimental pathology. 8(4) |
| ISSN: |
1936-2625 |
| Popis: |
Cancer testis antigens (CTAs) are selectively expressed in malignant cells and can serve as ideal targets for immunotherapy. We investigated the expressions of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 to determine if combinatorial expressions of CTAs might be as potential prognostic markers for patients with hepatocellular carcinoma (HCC). In tumor tissues of 142 HCC patients, the mRNA expressions of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 were 78.9%, 33.8%, 74.6% and 14.1% respectively. Furthermore, the expressions of MAGE-A3, MAGE-A4 and combination of MAGE-A3, MAGE-A4 and NY-ESO-1 (CTAs-A3/A4/NY) showed positive correlations with serum AFP, tumor stages and Ki-67 (P < 0.05). In addition, mRNA expressions of CTAs were significantly consistent with protein expressions of CTAs by immunohistochemistry (P > 0.05). Receiver operating characteristic curves (ROC) analysis showed that CTAs-A3/A4/NY had larger areas under ROC curve (0.768), specificity (99.1%), Youden’s index (44.6), positive predictive value (90.9%) and negative predictive value (89.9%) for predicting HCC recurrence than other CTAs. Moreover, the combinatorial expression of CTAs-A3/A4/NY was significantly associated with HCC recurrence by Kaplan-Meier analysis (HR = 69.36, P < 0.01) and multivariate Cox analysis (RR = 17.11, P < 0.01). The combinatorial expression of CTAs-A3/A4/NY mRNA promotes the predictive accuracy of HCC recurrence and itself may be a potential target for immunotherapy of HCC as well. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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