| Autor: |
M, Hatsuse, C, Shimazaki, Y, Tsubakimoto, N, Ochiai, A, Okano, E, Ashihara, T, Inaba, N, Fujita, M, Nakagawa |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
[Rinsho ketsueki] The Japanese journal of clinical hematology. 42(2) |
| ISSN: |
0485-1439 |
| Popis: |
A 52-year-old man was admitted for treatment of acute lymphoblastic leukemia (ALL). The bone marrow was hypercellular with 67.2% blasts, which were negative for peroxidase, and expressed CD13, CD33, CD34, CD10 and CD7. Cytogenetic and molecular studies revealed t(9;22) and -7(Ph/-7) with major BCR/ABL rearrangement. The patient was treated with the L-AdVP regimen, but failed to achieve complete remission (CR). He then received two courses of chemotherapy consisting of intermediate- and high-dose cytarabine (ara-C), resulting in CR. This case suggests that Ph/-7 ALL with major BCR/ABL gene rearrangement showing coexpression of myeloid antigens may be sensitive to intermediate- and high-dose ara-C. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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