[Homocysteine and methylmalonic acid. New tests--for what benefit?]

Autor:	S, Berentsen, I, Talstad
Rok vydání:	1996
Předmět:	Evaluation Studies as Topic Humans Mass Screening Vitamin B 12 Deficiency Amino Acids Homocysteine Methylmalonic Acid
Zdroj:	Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke. 116(22)
ISSN:	0029-2001
Popis:	A serum cobalamin level lower than 250 pmol/l combined with high values of plasma homocysteine and serum methylmalonic acid confirms the diagnosis of vitamin B12 deficiency. A low serum and erythrocyte folate level and high plasma homocysteine confirm folate deficiency. If the cobalamin level is higher than 250 pmol/l no further tests are needed. In patients with neurologic or psychiatric disorders combined with elevated levels of homocysteine and methylmalonic acid, cobalamin deficiency is likely if these levels decrease during vitamin B12 therapy. The causes of elevated homocysteine levels are often obscure, and homocysteine should therefore not be used as a screening test.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5b23ae7d5c871ad2e607ed3f20e64f79 https://pubmed.ncbi.nlm.nih.gov/8928147 Zobrazit plný text záznamu