Diagnostic Accuracy of 2-[

Autor: Ali, Rashidi, Lucia, Baratto, Ashok Joseph, Theruvath, Elton Benjamin, Greene, K Elizabeth, Hawk, Rong, Lu, Michael P, Link, Sheri L, Spunt, Heike E, Daldrup-Link
Rok vydání: 2021
Předmět:
Zdroj: Eur Radiol
ISSN: 1432-1084
Popis: OBJECTIVES: To compare the diagnostic accuracy of 2-[(18)F]fluoro-2-deoxy-D-glucose enhanced positron emission tomography (2-[(18)F]FDG-PET) and diffusion-weighted magnetic resonance imaging (DW-MRI) for the detection of bone marrow metastases in children and young adults with solid malignancies. METHODS: In this cross-sectional single-center institutional review board-approved study, we investigated twenty-three children and young adults (mean age, 16.8 years +/− 5.1 [standard deviation]; age range, 7–25 years; 16 males, 7 females) with 925 bone marrow metastases who underwent 66 simultaneous 2-[(18)F]FDG-PET and DW-MRI scans including 23 baseline scans and 43 follow-up scans after chemotherapy between May 2015 and July 2020. Four reviewers evaluated all foci of bone marrow metastasis on 2-[(18)F]FDG-PET and DW-MRI to assess concordance and measured the tumor-to-bone marrow contrast. Results were assessed with a one-sample Wilcoxon test and Generalized Estimation Equation. Bone marrow biopsies and follow-up imaging served as the standard of reference. RESULTS: The reviewers detected 884 (884/925, 95.5%) bone marrow metastases on 2-[(18)F]FDG-PET and 893 (893/925, 96.5%) bone marrow metastases on DW-MRI. We found different “blind spots” for 2-[(18)F]FDG-PET and MRI: 2-[(18)F]FDG-PET missed sub-centimeter lesions while DW-MRI missed lesions in small bones. Sensitivity and specificity were 91.0% and 100% for (18)F-FDG-PET, 89.1% and 100.0% for DW-MRI, and 100.0% and 100.0% for combined modalities, respectively. The diagnostic accuracy of combined 2-[(18)F]FDG-PET/MRI (100.0%) was significantly higher compared to either 2-[(18)F]FDG-PET (96.9%, p
Databáze: OpenAIRE
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