Cyclic Peptide Screening Methods for Preclinical Drug Discovery

Autor:	Xinting, Li, Timothy W, Craven, Paul M, Levine
Rok vydání:	2022
Předmět:	Peptide Library Drug Discovery RNA Messenger Peptides Cyclic
Zdroj:	Journal of medicinal chemistry. 65(18)
ISSN:	1520-4804
Popis:	Cyclic peptides are among the most diverse architectures for current drug discovery efforts. Their size, stability, and ease of synthesis provide attractive scaffolds to engage and modulate some of the most challenging targets, including protein-protein interactions and those considered to be "undruggable". With a variety of sophisticated screening technologies to produce libraries of cyclic peptides, including phage display, mRNA display, split intein circular ligation of peptides, and
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5b0976d0ef426ba3f08e32a12d3f689b https://pubmed.ncbi.nlm.nih.gov/36074956 Zobrazit plný text záznamu