| Autor: |
Shakhov YuA, I E, Petrichenko, N V, Chepurnenko, N V, Perova, R G, Oganov |
| Rok vydání: |
1989 |
| Předmět: |
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| Zdroj: |
Biochemistry international. 18(5) |
| ISSN: |
0158-5231 |
| Popis: |
It has been found that lymphocytes of hypercholesterolemic (HCh) subjects are characterized by a reduced number of glucocorticoid receptors (GcR) as compared with the cells of normolipidemics (N). Addition of HCh-sera or very low density lipoproteins, or low density lipoproteins isolated both from HCh-sera and N-sera to cultured human skin fibroblasts brought about a fall in the number of GcR in the cells. High density lipoproteins had no effect on GcR level. Dexamethasone was less effective in inhibiting cholesterol synthesis from [14C]acetate in the lymphocytes and fibroblasts with a reduced number of GcR. In the presence of dexamethasone (I x 10(-8)M) in fibroblast growth medium, reduced number of GcR (due to preincubation with very low density lipoproteins) led to a substantial increase in cholesterol synthesis. These findings indicate that the sensitivity of peripheral cells to glucocorticoids is decreased in HCh which might be one of the trigger mechanisms of atherogenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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