Dinuclear platinum(II) complexes as the pattern for phosphate backbone binding: a new perspective for recognition of binding modes to DNA

Autor: Andjela A, Franich, Ivana S, Đorđević, Marija D, Živković, Snežana, Rajković, Goran V, Janjić, Miloš I, Djuran
Rok vydání: 2021
Předmět:
Zdroj: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 27(1)
ISSN: 1432-1327
Popis: The mechanism of action of most approved drugs in use today is based on their binding to specific proteins or DNA. One of the achievements of this research is a new perspective for recognition of binding modes to DNA by monitoring of changes in measured and stoichiometric values of absorbance at 260 nm. UV-Vis and IR spectroscopy, gel electrophoresis and docking study were used for investigation of binding properties of three dinuclear platinum(II) complexes containing different pyridine-based bridging ligands, [{Pt(en)Cl}
Databáze: OpenAIRE
Externí odkaz: