[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon]

Autor:	A M, Mendzheritskiĭ, G V, Karantysh, G A, Ryzhak, S V, Dem'ianenko
Rok vydání:	2014
Předmět:	Male Caspase 3 Interleukin-6 Tumor Necrosis Factor-alpha Neurogenesis Brain Apoptosis Rats Disease Models Animal Acute Disease Animals Intercellular Signaling Peptides and Proteins Hypoxia Peptides Oligopeptides
Zdroj:	Advances in gerontology = Uspekhi gerontologii. 27(1)
ISSN:	1561-9125
Popis:	While studying the effects of Cortexin and Pinealon (Glu-Asp-Arg) on the caspase-3 activity in the brain, an interleykin-6 and a factor of tumor necrosis in blood serum of old rats under the sharp hypoxic hypoxia it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level. With the sharp hypoxic hypoxia Cortexin reduces an ability of brain tissue of programmed cells death, but saves the content of interleykin-6 at high level.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5ae792d9abfd9522b26dd78b4d004ddb https://pubmed.ncbi.nlm.nih.gov/25051764 Zobrazit plný text záznamu