Reduced prevalence of obesity in children with primary fructose malabsorption: a multicentre, retrospective cohort study

Autor:	S C, Disse, A, Buelow, R-H, Boedeker, K-M, Keller, H-S, Kim-Berger, S A, Wudy, K-P, Zimmer
Rok vydání:	2012
Předmět:	Male Pediatric Obesity Adolescent Fructose Body Mass Index Cohort Studies Logistic Models Intestinal Absorption Malabsorption Syndromes Child Preschool Prevalence Humans Female Child Retrospective Studies
Zdroj:	Pediatric obesity. 8(4)
ISSN:	2047-6310
Popis:	Studies in animals and in man have demonstrated that excessive consumption of fructose can cause all components of the metabolic syndrome.To investigate the impact of a condition resulting in decreased absorption of fructose, on obesity.In a multicentre study, we analyzed a cohort of paediatric patients with suspected primary fructose malabsorption (FM). Patients with chronic intestinal diseases were excluded. The final cohort comprised 628 patients.302 patients were diagnosed with primary FM (48.1%). The proportion of obese patients was lower among FM patients, compared to non-FM patients (2.3 vs. 6.1%, P = 0.029). Logistic regression analysis with inclusion of various covariates showed that FM was negatively associated with obesity (OR 0.35, 95% CI [0.13; 0.97]). We discuss several mechanisms involving the metabolic, endocrine and gastrointestinal system.Our data indicate that primary FM is negatively associated with childhood obesity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::5ad612f1264180096d1ea107254a4a4e https://pubmed.ncbi.nlm.nih.gov/23625781 Zobrazit plný text záznamu Plný text