| Autor: |
H P, Breuel, H J, Weimann, W, Dahmen, H J, Hausleiter, S, Bondy |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Arzneimittel-Forschung. 41(12) |
| ISSN: |
0004-4172 |
| Popis: |
Pharmacokinetics and relative bioavailability of the marketed prajmalium bitartrate tablet (Neo-Gilurytmal, CAS 2589-47-1) compared to an oral solution were investigated in an open, randomized, single-dose two-fold crossover study in 20 healthy male volunteers. One subject was identified to be a poor metabolizer. In the study population with normal metabolic status the two oral formulations proved to be bioequivalent with regard to the pharmacokinetic parameters Cmax, AUC(0-Tlast), AUC(0-infinity) and Ae(24h). tmax was prolonged after administration of the tablets. The relative bioavailability of prajmalium bitartrate from the tablet amounted to 112%. The poor metabolizer demonstrated in both oral formulations high plasma concentrations, increased AUCs and prolonged terminal half-lives as well as increased renal excretion of prajmalium bitartrate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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