Vascular expression of glucose transporter in experimental brain neoplasms
| Autor: | C, Guerin, J, Laterra, L R, Drewes, H, Brem, G W, Goldstein |
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| Rok vydání: | 1992 |
| Předmět: |
Male
endocrine system Monosaccharide Transport Proteins Brain Neoplasms nutritional and metabolic diseases Rats Inbred Strains Immunohistochemistry Rats Inbred F344 Rats carbohydrates (lipids) Capillary Permeability Glial Fibrillary Acidic Protein Tumor Cells Cultured Animals Blood Vessels Female hormones hormone substitutes and hormone antagonists Neoplasm Transplantation Research Article |
| Zdroj: | The American journal of pathology. 140(2) |
| ISSN: | 0002-9440 |
| Popis: | Vascular abnormalities in brain neoplasms are important to tumor biology and therapy. Glucose transporter (GLUT1) expression is a differentiated property of normal cerebral microvessels typically associated with expression of the blood-brain barrier. We investigated the relationship of GLUT1 expression to other vascular characteristics in F98, 9L, and C6 gliomas and Walker 256 carcinomas implanted into adult rat brains. The percentages of microvessels with immunohistochemically detectable GLUT1 were 95.5 +/- 3.9 in F98, 60.9 +/- 3.9 in 9L, 45.4 +/- 5.6 in C6, and 1.2 +/- 0.3 in Walker 256 (mean +/- SEM). The percentage of GLUT1-positive vessels in F98 was not statistically different from that in normal brain. GLUT1 expression was not dependent on restricted permeability as all tumors were highly permeable to Evans blue. GLUT1 expression was unrelated to vascular density, vascular morphology, and parenchymal GFAP expression. The expression of GLUT1, a marker of cerebral endothelial differentiation, is a newly described property of glial tumor vessels that may have diagnostic and prognostic significance. |
| Databáze: | OpenAIRE |
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