| Autor: |
Kh M, Kasumov, S D, Karakozov |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Biofizika. 30(2) |
| ISSN: |
0006-3029 |
| Popis: |
Amphotericin B which was added to the one side of a membrane in aqueous solutions with low pH 3.0 sharply increases the membrane conductance by the mechanism of channel forming. Long living ionic channels (20 sec) with large conductance dispersion (2-20 Ps) were found at the concentration 2 X 10(-8) M. Amphotericin B concentration which is necessary for obtaining single channels does not depend on cholesterol concentration in the membrane-forming solution in the range from 2 to 10 mg/ml. The effect of amphotericin B on the membrane depends on the phospholipid concentration in the membrane. The one-side selective permeability is the same as one under the symmetric action of the antibiotic. It is assumed that amphotericin B induced the membrane conductance by the mechanism of half-pores formation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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