| Autor: |
Cleópatra Alves, da Silva Caldeira, Rafaela, Diniz-Sousa, Daniel Carvalho, Pimenta, Ana Paula Azevedo, Dos Santos, Carolina Bioni Garcia, Teles, Najla Benevides, Matos, Saulo Luís, da Silva, Rodrigo Guerino, Stabeli, Silvia Andrea, Camperi, Andreimar Martins, Soares, Leonardo, de Azevedo Calderon |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Amino acids. 53(10) |
| ISSN: |
1438-2199 |
| Popis: |
The worrisome emergence of pathogens resistant to conventional drugs has stimulated the search for new classes of antimicrobial and antiparasitic agents from natural sources. Antimicrobial peptides (AMPs), acting through mechanisms that do not rely on the interaction with a specific receptor, provide new possibilities for the development of drugs against resistant organisms. This study sought to purify and proteomically characterize the antimicrobial and antiparasitic peptidomes of B. atrox and B. jararacussu snake venoms against Gram-positive (Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus-MRSA), Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) bacteria, and the protozoan parasites Leishmania amazonensis and Plasmodium falciparum (clone W2, resistant to chloroquine). To this end, B. atrox and B. jararacussu venom peptides were purified by combination of 3 kDa cut-off Amicon |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink