The partial nontandem duplication of the MLL (ALL1) gene is a novel rearrangement that generates three distinct fusion transcripts in B-cell acute lymphoblastic leukemia
| Autor: | S P, Whitman, M P, Strout, G, Marcucci, A G, Freud, L L, Culley, N J, Zeleznik-Le, K, Mrózek, K S, Theil, U R, Kees, C D, Bloomfield, M A, Caligiuri |
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| Rok vydání: | 2001 |
| Předmět: |
Gene Rearrangement
Reverse Transcriptase Polymerase Chain Reaction Chromosomes Human Pair 11 Recombinant Fusion Proteins Nuclear Proteins Chromosome Breakage Exons Histone-Lysine N-Methyltransferase Burkitt Lymphoma Translocation Genetic DNA-Binding Proteins Alternative Splicing Blotting Southern Proto-Oncogenes Tumor Cells Cultured Humans RNA Messenger Chromosomes Human Pair 9 Myeloid-Lymphoid Leukemia Protein Repetitive Sequences Nucleic Acid Transcription Factors |
| Zdroj: | Cancer research. 61(1) |
| ISSN: | 0008-5472 |
| Popis: | A partial nontandem duplication (PNTD) of mixed lineage leukemia (MLL) gene is described in B-cell acute lymphoid leukemia without structural cytogenetic abnormalities at 11q23 and 9p22. A duplicated portion of MLL is interrupted by the insertion of a region of 9p22 that includes the 3'-end of the AF9 gene. The PNTD encodes: (a) a PNTD transcript; (b) a partial tandem duplication of MLL; and (c) a chimeric transcript fusing MLL to the 3'-end of AF9, mimicking the t(9;11)(p22;q23) and expressed 1024-fold higher than the other two. The MLL PNTD, therefore, contributes toward leukemogenesis through simultaneous production of fusion transcripts that are otherwise encoded by three distinct genetic defects. |
| Databáze: | OpenAIRE |
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