Regulatory interactions of alphabeta and gammadelta T cells in glomerulonephritis
| Autor: | A R, Rosenkranz, S, Knight, S, Sethi, S I, Alexander, R S, Cotran, T N, Mayadas |
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| Rok vydání: | 2000 |
| Předmět: |
B-Lymphocytes
Immunity Cellular Macrophages Receptors Antigen T-Cell alpha-beta Kidney Glomerulus Gene Expression Mice Transgenic Receptors Antigen T-Cell gamma-delta Complement System Proteins CD8-Positive T-Lymphocytes Antibodies Basement Membrane Mice Inbred C57BL Mice Proteinuria Glomerulonephritis Immunoglobulin G Animals RNA Messenger |
| Zdroj: | Kidney international. 58(3) |
| ISSN: | 0085-2538 |
| Popis: | Several lines of evidence suggest that cellular immune mechanisms contribute to glomerulonephritis.The roles of alphabeta and gammadelta T cells in the pathogenesis of glomerulonephritis were investigated in a model of nephrotoxic nephritis in mice deficient in either T-cell population [T-cell receptor (TCR)beta and TCRdelta knockout mice]. The model, induced by the injection of rabbit anti-mouse glomerular basement membrane antibody, is characterized by the development of proteinuria and glomerular damage over a 21-day observation period in wild-type mice.Mice deficient in either alphabeta or gammadelta T cells developed minimal proteinuria and glomerular lesions and had a significant reduction in macrophage accumulation compared with wild-type mice. In gammadelta T-cell-deficient mice, circulating levels and glomerular deposition of autologous IgG were comparable to wild-type levels, while alphabeta T-cell-deficient mice had no autologous IgG production. Autologous antibody production was not required for the development of glomerulonephritis since mice that lack IgG and B cells (micro-chain-/-) developed similar proteinuria to that observed in wild-type mice.These studies suggest a proinflammatory role for both alphabeta and gammadelta T cells in glomerular injury, independent of the humoral response. This is the first demonstration, to our knowledge, that both T-cell subsets contribute to the progression of a disease, and it suggests that complex regulatory interactions between alphabeta and gammadelta T cells play a role in glomerular injury. |
| Databáze: | OpenAIRE |
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