The C type lectins DC-SIGN and L-SIGN: receptors for viral glycoproteins
| Autor: | Pierre-Yves, Lozach, Laura, Burleigh, Isabelle, Staropoli, Ali, Amara |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
viruses
envelope glycoproteins viral transmission Gene Expression Virus Attachment Receptors Cell Surface DC-SIGN Recombinant Proteins Article endothelial cells infection L-SIGN Viral Proteins Virus Diseases Viruses Humans endocytosis Lectins C-Type viral entry dendritic cells Cell Adhesion Molecules Glycoproteins HeLa Cells Protein Binding |
| Zdroj: | Glycovirology Protocols |
| ISSN: | 1064-3745 |
| Popis: | DC-SIGN and L-SIGN are C-type lectins that recognize carbohydrate structures present on viral glycoproteins and function as attachment factors for several enveloped viruses. DC-SIGN and L-SIGN enhance viral entry and facilitate infection of cells that express the cognate entry receptor (cis-infection). They are also able to capture viruses and transfer viral infections to other target cells (trans-infection). In this chapter, we will give an overview of protocols used to produce soluble viral glycoproteins at high levels and to study the molecular basis of viruses/DC-SIGN and L-SIGN binding and internalization. We will also describe techniques to investigate the molecular mechanisms by which DC-SIGN or L-SIGN spread viral infections. |
| Databáze: | OpenAIRE |
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