| Autor: |
P G, Baraldi, B, Cacciari, A, Leoni, M, Recanatini, M, Roberti, M, Rossi, S, Manfredini, V, Periotto, D, Simoni |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Farmaco (Societa chimica italiana : 1989). 46(11) |
| ISSN: |
0014-827X |
| Popis: |
A series of 4-diazopyrazole-5-carboxamides 1 d-n has been synthesized and their antibacterial activity against a number of Gram-negative and Gram-positive strains has been tested. Some of the compounds resulted quite active and the whole set allowed to further study the SAR of the class. Substituents in position 5 affect Gram-negative and Gram-positive activities via bulk and electronic properties respectively; position 3 mostly affects the Gram-negative activity, while the presence of the charged diazo group in position 4 is crucial for both antibacterial activities. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
