Quantitative In Vivo Monitoring of Hypoxia and Vascularization of Patient-Derived Murine Xenografts of Mantle Cell Lymphoma Using Photoacoustic and Ultrasound Imaging

Autor:	Peter, Keša, Eva, Pokorná, Martina, Grajciarová, Zbyněk, Tonar, Petra, Vočková, Philippe, Trochet, Milan, Kopeček, Radek, Jakša, Luděk, Šefc, Pavel, Klener
Rok vydání:	2020
Předmět:	Neovascularization Pathologic Lymphoma Mantle-Cell Multimodal Imaging Cell Hypoxia Tumor Burden Oxygen Photoacoustic Techniques Hemoglobins Mice Oxyhemoglobins Microvessels Animals Humans Female Ultrasonography Doppler Color Microvascular Density Neoplasm Transplantation
Zdroj:	Ultrasound in medicinebiology. 47(4)
ISSN:	1879-291X
Popis:	Tumor oxygenation and vascularization are important parameters that determine the aggressiveness of the tumor and its resistance to cancer therapies. We introduce dual-modality ultrasound and photoacoustic imaging (US-PAI) for the direct, non-invasive real-time in vivo evaluation of oxygenation and vascularization of patient-derived xenografts (PDXs) of B-cell mantle cell lymphomas. The different optical properties of oxyhemoglobin and deoxyhemoglobin make it possible to determine oxygen saturation (sO
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::59d1732ec3997f083dde6bd0d0780c39 https://pubmed.ncbi.nlm.nih.gov/33455807 Zobrazit plný text záznamu