| Autor: |
G, Gegova, N, Manolova, Iu, Serkedzhieva, V, Maksimova, S, Uzunov, D, Dzeguze, M, Indulen |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Acta microbiologica Bulgarica. 30 |
| ISSN: |
0204-8809 |
| Popis: |
The synergistic effect shown by the combination of a natural product, polyphenolic complex (PC) isolated from Geranium sanguineum L., and rimantadine (R) in vitro and in ovo [7], encouraged us to continue these studies by in vivo testing. A marked protective effect in experimental influenza virus A (H3N2) infection in mice was found when PC was applied nasally (i.n.) (1.0 mg/kg) only once 6 h before infection in combination with R applied orally in concentration 10.5 and 2.5 mg/kg 2h before and 2.24 and 48 h after viral inoculation (PI = 72.55%, 55% and 57.8% respectively). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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