[Delayed neurotoxic action of a new fungicide aphos]

Autor:	I I, Tkachenko, Iu S, Kagan, N V, Kokshareva, L N, Badaeva
Rok vydání:	1985
Předmět:	Time Factors Dose-Response Relationship Drug Neuromuscular Junction Action Potentials Peripheral Nervous System Diseases Synaptic Transmission Fungicides Industrial Organophosphate Poisoning Organophosphorus Compounds Animals Emulsions Female Peripheral Nerves Drug Contamination Chickens
Zdroj:	Farmakologiia i toksikologiia. 48(6)
ISSN:	0014-8318
Popis:	It has been established that administration of aphos to chickens within a wide dose range (3000-25 mg/kg) produces a retarded neurotoxic action that is manifested by the development of ataxia, pareses and paralyses; delay in the rate of the distribution of excitation via the peripheral axons, disorders of myoneural lability; degeneration of myelin fibers, focal granular degradation of myelin. The retarded neurotoxic action is not caused by impurities contained by the technical-grade preparation in view of the fact that such an action is also common to the chemically pure aphos.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::59973fc34c39104ab28cb6e8e36e96f6 https://pubmed.ncbi.nlm.nih.gov/3002846 Zobrazit plný text záznamu