| Autor: |
Liuxin, Long, Jing, Tian, Xi, Xie, Fen, Li, Suqing, Xu |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 47(7) |
| ISSN: |
1672-7347 |
| Popis: |
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can affect almost every organ in the human body. The etiology and pathogenesis are unclear. Recent studies have shown that pathogenesis and development of SLE result from the interaction between various internal and external factors. Current studies suggest that air pollution may increase the risk of SLE through multiple mechanisms such as inducing immune disorders, causing epigenetic changes, and inducing oxidative stress. Air pollution has a certain relationship with pulmonary interstitial lesions, lupus nephritis, decreased reproductive function and other system damages in SLE patients, and it is related to the occurrence and clinical outcomes of SLE. Air pollution has a potential role in the occurrence and development of SLE, providing a brand-new view on the early prevention and control of SLE.系统性红斑狼疮(systemic lupus erythematosus，SLE)是一种可累及全身多器官系统的自身免疫性疾病，其病因和发病机制尚不明确。研究认为其发生与发展是多种内外因素共同作用的结果，其中空气污染可通过诱导免疫紊乱、引起表观遗传学改变、诱发氧化应激等一系列机制增加SLE发生与发展的风险。空气污染与SLE患者肺间质病变、狼疮肾炎、生殖功能下降等存在一定关系，与SLE的发生和临床结局相关。空气污染在SLE发生与发展中存在潜在作用，为加强SLE早期防控提供了新思路。. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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