In vitro antiviral effect of flavonoid-rich extracts of Vitex polygama (Verbenaceae) against acyclovir-resistant herpes simplex virus type 1

Autor:	J L, Gonçalves, S G, Leitão, F D, Monache, M M, Miranda, M G, Santos, M T, Romanos, M D, Wigg
Rok vydání:	2002
Předmět:	Flavonoids Plant Leaves Vitex Dose-Response Relationship Drug Plant Extracts Fruit Tumor Cells Cultured Acyclovir Humans Herpesvirus 1 Human Antiviral Agents
Zdroj:	Phytomedicine : international journal of phytotherapy and phytopharmacology. 8(6)
ISSN:	0944-7113
Popis:	Extracts and fractions rich in flavonoids from fruits and leaves of Vitex polygama Cham. (Verbenaceae) were tested against acyclovir-resistant herpes simplex virus type 1 (ACV-HSV-1). Both fruit and leaf extracts exhibited a dose-dependent antiviral activity. The extract from the leaves showed intracellular antiviral activity while the extract from the fruits had virucidal effect. A fraction from the ethyl actetate extract of the leaves inhibited virus propagation by blocking HEp-2 cell receptors.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::594cce0854014e17edb75577ae529aaf https://pubmed.ncbi.nlm.nih.gov/11824525 Zobrazit plný text záznamu Full Text from ScienceDirect