| Autor: |
Abhineet, Uppal, Stacey, Stern, John F, Thompson, Leland, Foshag, Nicola, Mizzollo, Omgo E, Nieweg, Harald J, Hoekstra, Daniel F, Roses, Vernon K, Sondak, Mohammed, Kashani-Sabet, Brendon J, Coventry, Alistair J, Cochran, Manabu, Fujita, Myung, Sim-Shin, David, Elashoff, Robert M, Elashoff, Mark B, Faries |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Annals of surgical oncology. 27(6) |
| ISSN: |
1534-4681 |
| Popis: |
Recommended treatment for patients with sentinel lymph node (SLN)-positive melanoma has recently changed. Randomized trials demonstrated equivalent survival with close observation versus completion lymph node dissection (CLND), but increased regional node recurrence. We evaluated factors related to in-basin nodal recurrence after lymphadenectomy (LND) for SLN-positive or macroscopic nodal metastases.An institutional database and the first Multicenter Selective Lymphadenectomy Trial (MSLT-I) were analyzed independently. Exclusions were multiple primaries, multi-basin involvement, or in-transit metastases. Patient demographics, primary tumor thickness and ulceration, lymph nodes retrieved, and use of adjuvant radiotherapy were analyzed. Multivariate analyses were performed to determine factors predicting in-basin nodal recurrence (significance p ≤ 0.05).The retrospective cohort (577 patients) showed an in-basin failure rate of 6.6% after CLND for a positive SLN and 13.1% after LND for palpable disease (p = 0.001). This recurrence risk persisted after adjustment for patient, tumor, and LND factors [hazard ratio (HR) 2.32; p = 0.004]. In the MSLT-I cohort (326 patients), the failure rate after CLND following SLNB was 6.2%, but 10.1% after LND for palpable recurrence in observation patients. After adjustment for other factors, macroscopic disease was associated with an increased risk of recurrence after LND (HR 2.24; p = 0.05).After LND for melanoma, in-basin recurrence is infrequent, but a clinically significant fraction will fail. Failure is less likely if dissection is performed for clinically occult disease. Further research is warranted to evaluate the long-term regional control and quality of life associated with nodal basin observation, which has now become standard practice. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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